DrMemory is a tool for detecting memory errors and misuse of Windows APIs.
I've tried portable version 1.8.1RC1 on Windows 7 32bit (it doesn't support Windows 10 and 64bit).
I ran it as:
..\drmemory\bin\drmemory.exe -logdir ..\drmemlogs -suppress=drmem-sup.txt — .\rel\SumatraPDF.exe ..\f1.pdf
There are what appear to be false positives. I add suppressions to drmem-sup.txt as I find them.
DrMemory visibly slows down the program and also crashes sometimes (e.g. it crashed for me with XPS files).